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Target intelligence / Profile preview
Zinc finger protein 267 (ZNF267)
- Target
- ZNF267
- Molecular classification
- Transcription factor, Zinc finger protein, DNA-binding protein
01
Overview
Zinc finger protein 267 (ZNF267) is a Kruppel-like transcription factor that binds DNA and acts primarily as a transcriptional repressor, notably suppressing the MMP-10 gene promoter in hepatic stellate cells and thereby limiting extracellular matrix degradation, which promotes fibrotic liver remodeling. Its expression is regulated by nuclear factor Y and is markedly increased in liver pathologies such as fibrosis and hepatocellular carcinoma. ZNF267 is further inducible under hypoxic and oxidative stress conditions (notably through HIF1α and ROS signaling), and it contributes to tumor cell proliferation and migration in liver cancer. While primarily studied in liver disease and malignancy, ZNF267 and related zinc finger proteins may play broader roles in other cancers, as suggested by emerging evidence in colorectal cancer, but it is not considered a classic therapeutic target at present[1][2][3][4][6].
- Other names
- HZF2ZN267_HUMANZinc finger protein HZF2Zinc finger (C2H2)
02
Biological functions
Regulation of transcriptionTranscriptional repressor activityDNA bindingRNA polymerase II-specific regulationNegative regulation of extracellular matrix degradation
03
Disease associations
CancerLiver fibrosisHepatocellular carcinomaNon-alcoholic fatty liver diseaseColorectal cancer
04
Biomarkers
High expression in hepatic stellate cell activationUp-regulated in hepatocellular carcinomaUp-regulated in non-alcoholic fatty liver diseaseModulation during hypoxia (via HIF1α)
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