Zinc finger protein 280B (ZNF280B)

Zinc finger protein 280B (ZNF280B) is a member of the C2H2-type zinc finger transcription factor family, characterized by multiple zinc finger domains that facilitate DNA binding and regulation of gene expression[1][5]. As a transcription factor, ZNF280B is implicated in regulating cell proliferation and survival, especially in cancer contexts such as prostate and gastric cancers[1][2][3]. In prostate cancer, ZNF280B promotes tumor growth by up-regulating the expression of the Mdm2 gene, which in turn leads to degradation of the tumor suppressor protein p53 via enhanced proteasomal degradation—a key pro-survival and pro-growth mechanism in tumorigenesis[1]. In gastric cancer, increased ZNF280B expression is associated with larger tumor size, advanced stage, and increased proliferation, suggesting an oncogenic function[2][3]. The protein's exact mechanisms and broader physiological roles remain under investigation, but its effect on the Mdm2-p53 axis and correlation with cancer progression support its identification as a molecular target in oncology research[1][2].

Other names

Zinc finger protein 280BZNF280BSUHW2ZNF279ZNF632Suppressor of hairy wing homolog 2Zinc finger protein 279Zinc finger protein 632D87009.C22.35'OY11.1