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Target intelligence / Profile preview
Zinc finger protein 3 (ZNF3)
- Target
- ZNF3
- Molecular classification
- Transcription factor, Zinc finger protein, C2H2-type zinc finger
01
Overview
Zinc finger protein 3 (ZNF3) is a member of the C2H2-type zinc finger transcription factor family that enables DNA binding and identical protein binding activity; it is predicted to regulate transcription by RNA polymerase II and is primarily active in the nucleus. ZNF3 is implicated in cell differentiation and proliferation. Diseases genetically associated with alterations in ZNF3 include certain bleeding disorders and maturity-onset diabetes of the young, though there is little evidence for direct targeting or therapeutic modulation of ZNF3 by drugs[1][3][9].
- Other names
- A8-51KOX25PP838FLJ20216HF.12Zfp113zinc finger protein HF.12zinc finger protein HZF3.1zinc finger protein KOX25
02
Biological functions
Regulation of transcription by RNA polymerase IICell differentiationCell proliferationProtein bindingNucleic acid binding
03
Disease associations
Bleeding disorder, platelet-type, 17Maturity-onset diabetes of the young, type 4Other
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