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Target intelligence / Profile preview
Zinc finger protein 300 (ZNF300)
- Target
- ZNF300
- Molecular classification
- Transcription factor, C2H2-type zinc finger protein, KRAB (Krüppel-associated box) domain-containing protein
01
Overview
Zinc finger protein 300 (ZNF300) is a member of the KRAB (Krüppel-associated box) and C2H2-type zinc finger protein family, functioning primarily as a transcriptional repressor. ZNF300 binds to specific DNA sequences, modulating the transcription of multiple genes, likely through mechanisms involving both DNA methylation and histone modification. It is implicated in the regulation of cell differentiation—particularly in hematopoietic (blood) cells—and is dysregulated in several cancers, including leukemia and cervical cancer. However, ZNF300 is not currently established as a direct therapeutic target, nor are drugs or clinical biomarkers specifically associated with this protein[1][2][3].
- Other names
- ZNF300Kruppel-like zinc finger proteinzinc finger protein 300KRAB-ZNF300
02
Biological functions
Transcriptional repressionDNA bindingRegulation of gene expression (likely, via repression)Epigenetic regulation (including DNA methylation and histone modification)Modulation of cell differentiation (notably blood and immune cells)
03
Disease associations
Cancer (including leukemia, cervical cancer)Hematological disorders (blood cell maturation and differentiation)
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