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Target intelligence / Profile preview
Zinc finger protein 32 (ZNF32)
- Target
- ZNF32
- Molecular classification
- Transcription factor, Zinc finger protein (C2H2 type)
01
Overview
Zinc finger protein 32 (ZNF32), also known as KOX30, is a protein-coding gene in humans that encodes a member of the C2H2 zinc finger transcription factor family. It is predicted to bind DNA in a sequence-specific manner and to regulate transcription by RNA polymerase II[3][8]. Structural studies have determined the solution structures of specific zinc finger domains within this protein[1][2]. The protein is localized to the nucleus[3] and has been shown to act as an autophagy inhibitor in breast cancer cells, protecting them from stimulus-induced cell death[7]. ZNF32 is associated with the disease granulomatous orchitis[3]. There is currently no direct evidence in the provided literature that ZNF32 is a therapeutic target or that there are drugs known to interact with it.
- Other names
- KOX30ZNF637Zfp637C2H2-546Zinc finger protein KOX30Zinc finger protein 32 (KOX 30)
02
Biological functions
Sequence-specific double-stranded DNA bindingRegulation of transcription by RNA polymerase IITranscriptional regulationAutophagy inhibition in breast cancer cells
03
Disease associations
Granulomatous orchitis
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