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Target intelligence / Profile preview
Zinc finger protein 322 (ZNF322)
- Target
- ZNF322
- Molecular classification
- Transcription factor, Zinc finger protein, C2H2-type zinc finger family
01
Overview
Zinc finger protein 322 (ZNF322) is a transcriptional activator and a member of the C2H2-type zinc finger transcription factor family. It promotes gene transcription and is involved in positive regulation of stem cell maintenance, pluripotency, and embryonic heart development through regulation of MAPK signaling pathways. ZNF322 binds directly to promoters and enhancers of key pluripotency factors such as POU5F1 and NANOG, influencing expression levels and stem cell fate decisions. It is expressed widely in adult and developing human tissues, and localizes to the nucleus and cytoplasm. Currently, ZNF322 is recognized for its role in transcriptional regulation rather than as a direct therapeutic target.
- Other names
- ZNF322AZNF388ZNF489HCG12bA457M11.2bA457M11.3
02
Biological functions
Gene transcription regulationTranscriptional activationStem cell pluripotency maintenanceRegulation of MAPK signaling pathwayRegulation of cardiac development
03
Disease associations
Heart developmentPossible relevance in pluripotency and differentiation (no strong therapeutic association documented)
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