Zinc finger protein 331 (ZNF331)

Zinc finger protein 331 is a DNA-binding transcription factor encoded by the ZNF331 gene in humans. It contains a KRAB (Kruppel-associated box) domain, seen in transcriptional repressors. ZNF331 has roles in regulating gene expression and acts as a transcriptional repressor through its binding to nucleic acids. It is considered a putative tumor suppressor, frequently silenced by promoter hypermethylation in several cancers, thereby contributing to tumorigenesis and cancer progression. High-frequency methylation and downregulation of ZNF331 are correlated with advanced disease states and poorer clinical outcomes, marking it as a potential diagnostic and prognostic tumor biomarker. The protein may also play a role in spermatogenesis. Note: - There is no evidence in the referenced sources that ZNF331 acts as a direct drug target, receptor, enzyme, or transporter; thus, it does not meet typical criteria for being a "therapeutic target" in the classic pharmacological sense at this time. - No interacting drugs or specific drug mechanisms targeting ZNF331 have been reported. - Main research and clinical interest currently focus on its function as a tumor suppressor and epigenetic biomarker rather than as a direct therapeutic target.

Other names

RITAZNF361ZNF463C2H2-like zinc finger protein rearranged in thyroid adenomasKRAB zinc finger proteinzinc finger protein 361zinc finger protein 463