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Zinc finger protein 335 (ZNF335)
- Target
- ZNF335
- Molecular classification
- Transcription factor, Chromatin remodeling protein
01
Overview
Zinc finger protein 335 (ZNF335) is a protein that functions as a transcription factor and chromatin remodeling regulator. It enhances transcriptional activation by ligand-bound nuclear hormone receptors, not via direct receptor binding but by interacting with nuclear hormone receptor coactivator NRC. ZNF335 is a component of histone methyltransferase complexes (notably, the trithorax H3K4-methylation complex) and is critical for neural progenitor cell proliferation, self-renewal, proper nervous system development, and the regulation of gene expression relevant to somatic and brain development. Loss-of-function mutations in ZNF335 cause autosomal recessive microcephaly and other severe developmental syndromes[1][3][6].
- Other names
- NIF-1bA465L10.2NRC-interacting factor 1MCPH10NIF1NIF2zinc-finger/leucine-zipper co-transducer NIF1
02
Biological functions
Regulation of gene expressionNeural progenitor cell proliferationNeural developmentHistone modificationTranscriptional activation by nuclear hormone receptors
03
Disease associations
Microcephaly (specifically Microcephaly 10, Primary, Autosomal Recessive)Microcephalic primordial dwarfism due to ZNF335 deficiencyBrain development disorders
04
Safety considerations
Loss-of-function mutations in ZNF335 cause severe neurodevelopmental defectsnot known to be a common or direct drug target
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