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Target intelligence / Profile preview
Zinc finger protein 337 (ZNF337)
- Target
- ZNF337
- Molecular classification
- Transcription factor, Zinc finger protein
01
Overview
Zinc finger protein 337 (ZNF337) is a protein containing multiple zinc finger motifs and is encoded by the ZNF337 gene on human chromosome 20p11.21. It functions as a putative transcription factor, likely involved in DNA binding and the regulation of transcription, though its precise functional roles remain unclear. ZNF337 is aberrantly expressed in multiple human cancer types, including kidney renal clear cell carcinoma, where high expression is associated with poor prognosis and increased cellular proliferation and migration. It contains KRAB, PHD, and several C2H2-type zinc finger domains, and exhibits several predicted post-translational modifications. While it has been implicated as a prognostic biomarker for several cancers, there are currently no known drugs that specifically target ZNF337[1][2][3].
- Other names
- ZNF337dJ694B14.1
02
Biological functions
Regulation of transcriptionDNA bindingRNA binding
03
Disease associations
CancerCorneal dystrophy, FleckCorneal dystrophy (general)
04
Biomarkers
Diagnostic and prognostic biomarker in kidney renal clear cell carcinoma (KIRC)potential biomarker in multiple cancers
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