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Zinc finger protein 34 (ZNF34)
- Target
- ZNF34
- Molecular classification
- Transcription factor, Zinc finger protein, KRAB-domain protein
01
Overview
Zinc finger protein 34 (ZNF34) is a member of the zinc finger protein family characterized by C2H2-type zinc finger motifs and a KRAB-A domain, functioning primarily as a transcriptional repressor[1][2][7]. It is predicted to regulate gene expression by binding specific DNA sequences and modulating transcription by RNA polymerase II[1][2][6][8]. ZNF34 is localized mainly in the cytosol and nucleoplasm and is expressed in several tissues, with notable expression in the brain[1][4]. Variants in ZNF34 have emerged in genetic studies as candidates influencing susceptibility to major depressive disorder and bipolar disorder, potentially through alteration of transcriptional repression in neural tissues[1]. There is currently no evidence that ZNF34 serves as a direct therapeutic target for any known drugs, nor is it recognized as a clinical biomarker or known for specific safety concerns[1][2][7].
- Other names
- KOX32Zinc finger protein KOX32zinc finger protein 34 (KOX 32)
02
Biological functions
Regulation of transcription by RNA polymerase IIDNA-binding transcription factor activityRNA polymerase II cis-regulatory region sequence-specific DNA binding
03
Disease associations
Psychiatric disorders (e.g., major depressive disorder, bipolar disorder)Other (no strong evidence for major somatic diseases or cancers)
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