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Zinc finger protein 341 (ZNF341)
- Target
- ZNF341
- Molecular classification
- Transcription factor, Zinc finger protein, C2H2-type zinc-finger domain-containing protein
01
Overview
Zinc finger protein 341 (ZNF341) is a C2H2-type zinc finger transcription factor that binds to specific DNA sequences and activates the transcription of the STAT3 gene and potentially other immune-related genes[2][7]. This regulation is crucial for maintaining immune homeostasis, especially for the differentiation and function of T helper 17 (Th17) cells and B cells. Biallelic mutations in ZNF341 lead to an autosomal recessive form of hyper-IgE syndrome (HIES), characterized by chronic infections and immune dysregulation similar to that seen with STAT3 deficiency[1][2][5]. ZNF341 is located on human chromosome 20.
- Other names
- Zinc finger protein 341ZNF341dJ553F4.3HIES3znf341
02
Biological functions
Regulation of DNA-templated transcriptionImmune response modulation (via activation of STAT3 and STAT1)Cell differentiation, especially T cell (Th17) and B cell development
03
Disease associations
Autosomal recessive hyper-IgE syndrome (HIES), with recurrent bacterial and fungal infections and immune deficienciesImmunodeficiencySkeletal abnormalities
04
Biomarkers
Elevated serum immunoglobulin E (IgE) for hyper-IgE syndromeReduced STAT3 protein and diminished Th17 cell counts in affected individuals
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