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Zinc finger protein 346 (ZNF346)
- Target
- ZNF346
- Molecular classification
- Transcription factor, Zinc finger protein, RNA-binding protein
01
Overview
Zinc finger protein 346 (ZNF346) is a nucleolar protein with several C2H2-type zinc finger domains, which preferentially binds to double-stranded RNA (dsRNA) and RNA/DNA hybrids over DNA alone. Its zinc finger regions are essential for both dsRNA binding and localization to the nucleolus. ZNF346 may play a role in cell growth and survival and is involved in protecting neurons by inhibiting inappropriate cell cycle re-entry, partly through stimulating p21 gene expression. ZNF346 is not established as a classical drug target and does not have known approved therapeutics or biomarker roles as of now, though it has been detected as a fusion partner in some cancer gene fusions[1][5][3].
- Other names
- JAZZfp346Just another zinc finger proteindouble-stranded RNA-binding zinc finger protein JAZ
02
Biological functions
Double-stranded RNA bindingRegulation of cell growth and survivalInhibition of cell cycle re-entry in neuronsNucleic acid binding
03
Disease associations
Cancer (as a fusion partner in rare gene fusions)Arthrogryposis multiplex congenita (neurogenic type)Mite infestation (very limited evidence)
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