Zinc finger protein 350 (ZNF350)

Zinc finger protein 350 (ZNF350), also known as ZBRK1, is a KRAB-containing zinc finger transcriptional repressor that binds specific DNA sequences (5'-GGGxxxCAGxxxTTT-3', e.g. in GADD45 intron 3) to repress gene expression. It interacts directly with the tumor suppressor BRCA1, and this interaction is crucial for its function in transcriptional repression, especially in the regulation of genes involved in DNA repair and cell cycle control. ZNF350 operates via two repression domains: an N-terminal KRAB domain that functions independently, and a C-terminal BRCA1-dependent domain that requires histone deacetylase activity. This protein is implicated in cancer biology, especially breast cancer, where the loss or dysregulation of ZNF350-mediated repression may contribute to tumorigenesis. It is located in nuclear bodies and acts as part of a transcriptional repressor complex, making it a relevant protein for gene regulation studies and potentially a therapeutic or diagnostic target in cancer. If additional information such as specific drug interactions or clinical biomarkers emerges in more specialized datasets, those details can be appended. Existing databases and reviewed literature, however, confirm its role as a transcriptional regulator with significant relevance to oncology, especially due to its BRCA1 interaction.

Other names

ZBRK1ZFQRKRAB zinc finger protein ZFQRZinc finger and BRCA1-interacting protein with a KRAB domain 1Zinc finger protein ZBRK1

Drugs targeting this protein would typically act as inhibitors or modulators of its binding, transcriptional repression, or protein-protein interaction (e.g., interference with the ZNF350-BRCA1 complex or its DNA-binding activity). No approved drugs or experimental compounds reported in the sources.