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Target intelligence / Profile preview
Zinc finger protein 354B (ZNF354B)
- Target
- ZNF354B
- Molecular classification
- Transcription factor, Chromatin-binding protein, DNA-binding protein (zinc finger family)
01
Overview
Zinc finger protein 354B (ZNF354B) is a protein-coding gene that encodes a transcriptional repressor belonging to the zinc finger family. It binds specifically to DNA, enabling regulation of gene expression through pathways associated with RNA polymerase II. Upon activation by RAS protein signaling, ZNF354B recruits other DNA-binding proteins and chromatin-modifying complexes to silence transcription at target loci, potentially playing a role in epigenetic gene regulation. ZNF354B is expressed mainly in the nucleus and is associated with diseases such as inflammatory bowel disease subtypes, but its role in other pathologies and as a therapeutic target remains under investigation[1][2][5][6].
- Other names
- ZNF354BKID2FLJ25008Zinc finger protein 354B
02
Mechanism of action
Not applicable; there are no known drugs directly targeting ZNF354B
03
Biological functions
Negative regulation of transcription by RNA polymerase IITranscriptional repressionChromatin remodelingRegulation of gene expression
04
Disease associations
Inflammatory bowel disease (specifically types 11 and 13)
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