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Zinc finger protein 362 (ZNF362)
- Target
- ZNF362
- Molecular classification
- Transcription factor, C2H2 zinc finger protein
01
Overview
Zinc finger protein 362 (ZNF362) is a protein-coding gene that encodes a predicted DNA-binding transcription factor, primarily enabling sequence-specific binding to cis-regulatory regions targeted by RNA polymerase II[1][2]. ZNF362 acts within the nucleus and is involved in the regulation of gene transcription. Disease associations include various forms of acute leukemia, and gene fusions involving ZNF362 have been observed in the context of B cell precursor acute lymphoblastic leukemia[1][4]. It belongs to the large family of C2H2 zinc finger transcription factors, but there is currently no evidence that ZNF362 is a direct therapeutic target or has clinically significant drug interactions[1][2][5][6].
- Other names
- LIN-29rotund homolog (Drosophila)PP6997FLJ25476RNzinc finger protein 362ZNF362lin-29rotund homolog
02
Biological functions
Regulation of transcription by RNA polymerase IIDNA-binding transcription factor activitysequence-specific DNA binding
03
Disease associations
Cancer (notably, mixed phenotype acute leukemia and B-lymphoblastic leukemia/lymphoma with TCF3-PBX1)Other
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