Zinc finger protein 367 (ZNF367)

Zinc finger protein 367 (ZNF367) is a member of the C2H2 zinc finger protein superfamily and functions as a DNA-binding transcription factor that regulates gene expression via RNA polymerase II. It is primarily located in the nucleus and is expressed in various tissues, notably in the brain and retina. ZNF367 plays important roles in neurogenesis, neuronal differentiation, and cell cycle control, particularly controlling the metaphase-to-anaphase transition and maintaining chromosome stability. Knockdown studies in vertebrates show that ZNF367 is essential for proper cell cycle exit and neuronal differentiation but is not involved in the initial specification of neurons. Dysregulation of ZNF367 has been implicated in cancer progression and neurodevelopmental disorders, but as of September 2025, it is not a direct therapeutic target nor are there drugs known to interact with it or exploit its mechanisms of action[1][2][3][5][9].

Other names

ZNF367ZFF29FLJ33970C2H2 zinc finger protein ZFF29AFF29zinc finger protein 367CDC14 cell division cycle 14 homolog B (likely an annotation error, not a standard alias for ZNF367)C2H2 zinc finger protein ZFF29a

None directly established — it functions by regulating transcription and cell cycle; mechanisms for drugs have not been identified in the literature