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Target intelligence / Profile preview
Zinc finger protein 37 homolog (ZFP37)
- Target
- ZFP37
- Molecular classification
- Transcription factor (C2H2-type zinc finger protein)
01
Overview
Zinc finger protein 37 homolog (ZFP37) is a sequence-specific DNA-binding transcription factor and a structural protein of the neuronal nucleus, implicated in maintenance of specialized chromatin domains, particularly in centromeric/nucleolar regions of neurons[1][2][4][5]. It contains a truncated Krüppel-associated box (KRAB) domain and a histone H1-like linker, supporting chromatin structural functions. Its expression is found predominantly in the developing nervous system and adult brain or testis in mice[2][6]. ZFP37 belongs to the largest family of transcription factors, characterized by zinc ion binding and sequence-specific interaction with regulatory regions of DNA[1][5]. No evidence suggests direct involvement in drug targeting or disease pathology for the homolog itself.
- Other names
- ZFP37ZNF906ZFP-37zfp-37Zinc finger protein 37 homologzinc finger protein homologous to Zfp37 in mouse
02
Biological functions
Transcriptional regulationMaintenance of chromatin domains (especially in neuronal nuclei)
03
Disease associations
Other (Zinc finger proteins as a family are implicated in various cancers and neurological roles, but there is currently no direct disease association reported for ZFP37 itself)
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