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Target intelligence / Profile preview
Zinc finger protein 385B (ZNF385B)
- Target
- ZNF385B
- Molecular classification
- Transcription factor, Nucleic acid binding protein, Zinc finger protein
01
Overview
Zinc finger protein 385B (ZNF385B) is a nuclear transcription factor containing zinc finger domains responsible for nucleic acid binding[3][6]. It is involved in intrinsic apoptotic signaling via p53/TP53-mediated pathways, enabling p53 binding activity, and contributes to regulation of apoptosis within cells[2][3][8][1][10]. Expression of ZNF385B is nuclear and varies across tissues, with noted relevance in neurological tissues[7]. Genetic variations in ZNF385B are associated with autism spectrum disorder and may hold further yet-to-be-established disease roles[2]. No direct pharmacologic agents currently target this protein, and its biomedical significance lies chiefly in transcriptional regulation and apoptosis rather than as a direct therapeutic target.
- Other names
- ZNF385BZNF533FLJ25270Zinc finger protein 533zinc finger protein 385Bzinc finger protein 533
02
Biological functions
Intrinsic apoptotic signaling pathway by p53 class mediatorp53 binding activityNucleic acid binding
03
Disease associations
Autism spectrum disorder (associated via genetic studies)Other (potential cancer relevance based on apoptosis regulation, but not directly established as a disease gene)
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