Zinc finger protein 397 (ZNF397)

Zinc finger protein 397 (ZNF397) is a human transcription factor containing a N-terminal SCAN domain and multiple C2H2-type zinc finger repeats, which allow it to bind DNA and participate in transcriptional regulation[2][3]. ZNF397 functions as a coactivator of the androgen receptor, playing an essential role in maintaining androgen receptor-driven luminal lineage programs in prostate tissue[1]. Loss of ZNF397 induces lineage plasticity in prostate cancer cells via a switch to TET2-dependent epigenetic programs, promoting resistance to androgen receptor-targeted therapies[1]. Although not a receptor, enzyme, or traditional therapeutic target, ZNF397 is a transcriptional regulator with emerging roles in cancer progression and therapy resistance[1][2][3]. No drugs are currently known to directly target ZNF397, but TET2 inhibitors can reverse resistance phenotypes associated with its loss in preclinical models[1].

Other names

ZNF47ZSCAN15MGC13250Zinc finger and SCAN domain-containing protein 15Zinc finger protein 47

Modulation of epigenetic state via regulation of androgen receptor-driven transcriptional programs and interaction with TET2-dependent pathways