Zinc finger protein 398 (ZNF398)

Zinc finger protein 398 is a member of the Kruppel family of C2H2-type zinc-finger transcription factors, primarily functioning as a transcriptional activator in human cells[1]. It acts in concert with SMAD3 and the histone acetyltransferase EP300 to regulate gene expression, particularly at active promoters and enhancers[2]. In human pluripotent stem cells (hPSCs), ZNF398 is involved in maintaining pluripotency and epithelial characteristics and repressing genes associated with differentiation, such as those involved in neuroectodermal and mesenchymal transitions[2]. Two main isoforms are described: p71 (predominant in hPSCs, involved in pluripotency regulation) and p52 (promotes proliferation by ubiquitination of p53 in cancer cells)[2]. This protein is intracellular and lacks any known association with small molecule drug targeting or approved therapeutics[1][2][3]. Diseases associated with ZNF398 include certain cataracts and Gand syndrome, as well as roles linked to cancer biology[1][2].

Other names

ZNF398KIAA1339ZER6P51P71Zinc finger DNA-binding protein p52/p71zinc finger DNA binding protein ZER6zinc finger DNA binding protein p52/p71zinc finger-estrogen receptor interaction clone 6