Zinc finger protein 404 (ZNF404)

Zinc finger protein 404 is a member of the zinc finger protein family, likely acting as a transcription factor that binds to DNA in a sequence-specific manner to regulate gene expression, specifically through RNA polymerase II-dependent mechanisms[1][4][8][9]. It is predicted to be active in the nucleus and is associated with differential expression patterns in many tissues[6]. Genetic variants near ZNF404 modulate its expression and have been associated with phenotypes like breast cancer susceptibility[2]. However, ZNF404 itself is not currently considered a direct therapeutic target. Disease associations include certain forms of deafness and arthrogryposis, with the most established role relating to modulation of gene expression and chromatin state[1][2][7].

Other names

Zinc finger protein 404ZNF404

Not applicable. No available drugs or therapies reported to target ZNF404 directly.