Target intelligence / Profile preview

Zinc finger protein 418 (ZNF418)

Target: ZNF418
Molecular classification: Transcription factor, Zinc finger protein, Krueppel C2H2-type zinc finger family

Overview

Zinc finger protein 418 is a nuclear DNA-binding transcriptional repressor belonging to the Krueppel C2H2-type zinc finger family. It is involved in the regulation of transcription mediated by RNA polymerase II, as well as in cellular protein degradation processes such as the ubiquitin-proteasome and autophagy-lysosomal pathways. There is limited evidence associating ZNF418 with diseases, with some implication in ovarian squamous cell carcinoma, but it is not currently recognized as a therapeutic target

Other names: ZNF418KIAA1956FLJ31551ZFP418

Biological functions

DNA-binding transcription repressorRegulation of transcription by RNA polymerase IIRegulation of ubiquitin-proteasome systemRegulation of autophagy-lysosomal pathwayMicroautophagy

Disease associations

Cancer (notably implicated in ovarian squamous cell carcinoma)

Beyond the preview

Go deeper on Zinc finger protein 418 (ZNF418).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Zinc finger protein 418 (ZNF418).

Explore the full profile