Target intelligence / Profile preview

Zinc Finger Protein 423 (ZNF423)

Target: ZNF423
Molecular classification: Transcription factor, Zinc finger protein

Overview

Zinc finger protein 423 (ZNF423) is a nuclear protein that functions as a DNA-binding transcription factor. It utilizes its multiple zinc finger domains to participate in various signaling pathways, acting as both an activator and repressor of transcription depending on cellular context. ZNF423 plays roles in neurogenesis, adipogenesis, BMP signaling, and olfactory development. Mutations or dysregulation of ZNF423 are linked with Joubert Syndrome type 19, Nephronophthisis type 14, and various cancers.

Other names: EbfazJBTS19NPHP14OAZRoazZFP423Zfp104hOAZ

Biological functions

Transcriptional regulationNeurogenesisAdipogenesisBMP signaling

Disease associations

Joubert Syndrome type 19Nephronophthisis type 14Cancer

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