Target intelligence / Profile preview

Zinc finger protein 43 (ZNF43)

Target
ZNF43
Molecular classification
Transcription factor, C2H2-type zinc finger protein, KRAB domain-containing protein
01

Overview

Zinc finger protein 43 is a member of the C2H2-type zinc finger protein family, which is the largest family of transcription factors in humans[1][2][3]. This protein contains zinc finger motifs that enable it to bind DNA and function as a transcription factor, regulating the transcription of genes involved in development and potentially other cellular processes[2][3][4]. Like many C2H2 zinc finger proteins, ZNF43 possesses a KRAB domain implicated in protein-protein interactions and transcriptional repression[1][2][3]. Although the general family has established connections to gene regulation, tumorigenesis, cell proliferation, differentiation, apoptosis, and disease, the specific biological functions and molecular targets of ZNF43 itself remain uncharacterized[1][2][3][4]. There are no reported direct drug interactions, roles as a clinical biomarker, or known safety considerations.

Other names
KOX27ZNF39ZNF39L1HTF6zinc finger protein KOX27zinc finger protein 39zinc finger protein HTF6zinc finger protein 39-like 1 (KOX27)
02

Biological functions

Gene regulationDevelopmentProtein-protein interaction
03

Disease associations

CancerNeurodegenerative diseaseSkin diseaseDiabetesOther

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