Zinc finger protein 432 (ZNF432)

Zinc finger protein 432 (ZNF432) is a human protein encoded by the ZNF432 gene, classified in the C2H2-type zinc finger protein family. ZNF432 is characterized as a DNA-binding transcription factor that acts as a homologous recombination repressor and a poly(ADP-ribose) (PAR) "reader," dynamically participating in DNA damage response pathways. Mechanistically, ZNF432 is recruited to DNA lesions in a DNA- and parylation-dependent manner, where it can stimulate PARP1 activity and inhibit Exo1-mediated DNA end-resection, contributing to the regulation of genome stability. Experimental depletion of ZNF432 has been shown to increase Rad51 foci and alter DNA repair pathway engagement, confer resistance to PARP inhibition, and potentially impact cancer therapy outcomes. The protein is located in the nucleoplasm, and its dysregulation has been associated with roles in cancer development and inflammatory disorders such as inflammatory bowel disease, although the precise disease link remains to be further explored[3][1][4][2].

Other names

Zinc finger protein 432ZNF432KIAA0798

Potential modulation of PARP inhibitor sensitivity via inhibition of Exo-1–mediated DNA end-resection and stimulation of PARP1 activity[1][4]