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Target intelligence / Profile preview
Zinc finger protein 436 (ZNF436)
- Target
- ZNF436
- Molecular classification
- Transcription factor, Zinc finger protein
01
Overview
Zinc finger protein 436 (ZNF436) is a member of the zinc finger transcription factor family, predicted to function as a DNA-binding transcription factor and may act as a transcriptional repressor. It is involved in the regulation of gene transcription mediated by RNA polymerase II, and may negatively regulate transcription in certain signaling pathways, such as the MAPK pathway. Mutations in ZNF436 are associated with specific neurodevelopmental and neurodegenerative conditions, but it is not recognized as a therapeutic target, nor are its interacting drugs or mechanisms of action well-characterized in the literature[1][3][4][5][9].
- Other names
- ZNF436KIAA1710Zfp46zinc finger protein 436
02
Biological functions
Regulation of transcription by RNA polymerase IIDNA-binding transcription factor activityMay act as a transcriptional repressor
03
Disease associations
Autosomal dominant intellectual developmental disorder 40Frontotemporal dementia and/or amyotrophic lateral sclerosis 7
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