Zinc finger protein 44 (ZNF44)

Zinc finger protein 44 (ZNF44) is a member of the zinc finger protein family, characterized by the C2H2-type zinc finger DNA-binding motif. As a transcription factor, it binds to specific DNA sequences and regulates gene expression, primarily functioning as a transcriptional regulator for RNA polymerase II-dependent genes. Zinc finger proteins, including ZNF44, are highly versatile and can bind DNA, RNA, and proteins, participating in vital cellular processes such as cell differentiation, apoptosis, metabolism, stemness maintenance, and immune response. Zinc finger proteins overall are extensively studied in relation to cancer progression and potential clinical utility as therapeutic and diagnostic targets, although no direct drugs or clinical biomarkers are established for ZNF44. None specifically reported for ZNF44 as of current data. No drugs are cited to interact directly with ZNF44, though targeting zinc finger proteins as a class is possible. There are no validated biomarkers for ZNF44 patient selection or efficacy monitoring specifically; zinc finger proteins are emerging as prognostic markers in several cancers (e.g., hepatocellular carcinoma, but ZNF44 not listed as major marker). ZNF44’s aliases refer to different database entries, historical names, and alternative splice variants often used in the genomics and proteomics literature. The full spectrum of biological and clinical roles for ZNF44 may yet be underexplored, but the protein typifies zinc finger proteins' function in transcriptional regulation and gene expression control.

Other names

ZNF44GIOT2KOX7ZNF55ZNF58GIOT-2ZNF504Gonadotropin-inducible ovary transcription repressor 2Zinc finger protein 55Zinc finger protein 58Zinc finger protein KOX7zinc finger protein ZnFP12

Not applicable—no known drugs directly target ZNF44, but the general mechanism would be inhibition or modulation of transcription factor activity via DNA binding site blocking, degradation, or interfering protein-protein interactions