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Zinc finger protein 443 (ZNF443)
- Target
- ZNF443
- Molecular classification
- Transcription factor, Kruppel-type zinc finger protein, C2H2-type zinc finger protein
01
Overview
Zinc finger protein 443 is a member of the Kruppel-type C2H2 zinc finger protein family, characterized by the presence of conserved C2H2 motifs that enable binding to DNA and subsequent regulation of gene transcription. It may play roles in transcriptional regulation and chromatin remodeling, although specific molecular mechanisms and drug interactions have not been elucidated. ZNF443 is encoded on human chromosome 19 (HGNC:20878, NCBI Gene: 10224, UniProt: Q9Y2A4), and its function is dependent on metal ion binding for structural integrity of its DNA-binding domain. No credible sources identify it as a validated therapeutic target, nor are drug interactions, actionable biomarker roles, or major safety concerns reported.
- Other names
- ZNF443ZK1Krueppel-type zinc finger protein ZK1Kruppel-type zinc finger (C2H2)zinc finger protein 443
02
Mechanism of action
Not established for any drugs
03
Biological functions
Transcriptional regulationChromatin remodelingNucleic acid binding
04
Disease associations
Ectodermal dysplasia 11A, Hypohidrotic/Hair/Tooth Type, Autosomal Dominant (limited evidence of direct disease involvement)
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