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Zinc finger protein 444 (ZNF444)
- Target
- ZNF444
- Molecular classification
- Transcription factor, Zinc finger protein [C2H2-type zinc finger]
01
Overview
Zinc finger protein 444 is a protein-coding gene product that acts as a transcriptional regulator, particularly by activating transcription of a scavenger receptor gene involved in Ac-LDL degradation. It contains conserved zinc finger domains, which are structural motifs facilitating DNA binding. ZNF444 is located in a gene cluster on chromosome 19q13.4, with a pseudogene present on chromosome 15. Several transcript variants and isoforms have been identified. Zinc finger proteins are the largest family of transcription factors in the human genome, and are pivotal in diverse cellular processes including transcriptional regulation, cell cycle, apoptosis, differentiation, and metabolism—though for ZNF444 specifically, established biological roles remain primarily transcriptional regulation related to lipid metabolism.
- Other names
- ZNF444EZF-2EZF2ZSCAN17Endothelial zinc finger protein 2
02
Biological functions
Transcriptional regulation (activates/represses gene promoters)Regulation of scavenger receptor gene (involved in Ac-LDL degradation)
03
Disease associations
Possible association with bone sarcoma and soft tissue sarcoma (listed in disease databases, but evidence is limited)Other (No clear indication of direct involvement in major disease categories; being a transcription factor, broad roles in cell function are conceivable)
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