Zinc finger protein 461 (ZNF461)

Zinc finger protein 461 (ZNF461) is a member of the C2H2-type zinc finger protein family, characterized by the presence of a zinc finger motif that facilitates DNA binding[4][1]. It is predicted to function as a nucleic acid-binding transcription factor, involved in RNA polymerase II–dependent regulation of gene expression[2][4]. While its detailed physiological role is not fully delineated, ZNF461 is active in the nucleus and is believed to contribute to transcriptional control mechanisms. Human disease associations include lung non-small cell carcinoma and disorders of sex reversal, though its precise contribution to these conditions remains undefined[2]. There are no known drugs targeting ZNF461, nor is it established as a clinical biomarker. It is a protein-coding gene with several reported isoforms; functional studies suggest that it may participate in specialized transcriptional regulation within specific tissues[2][4].

Other names

ZNF461GIOT1GIOT-1MGC33911Gonadotropin-inducible ovary transcription repressor 1HZF28Zinc finger protein 28

None reported; as it is not recognized as a therapeutic target, mechanisms of action for drugs are not described