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Zinc finger protein 467 (ZNF467)
- Target
- ZNF467
- Molecular classification
- Transcription factor
01
Overview
Zinc finger protein 467 (ZNF467) is a transcription factor that binds DNA and regulates gene expression. Its function in humans is not fully elucidated, but the mouse ortholog is known to promote differentiation of adipocytes (fat cells) and suppress differentiation of osteoblasts (bone-forming cells) in bone marrow. It can recruit histone deacetylase complexes, interact with STAT3 at the acute phase response element (APRE), and activate transcription of several target genes involved in cell lineage commitment[1][2][5][7][8]. No direct links to therapeutically relevant disease processes or known drug interactions have been reported for the human protein.
- Other names
- ZNF467EZIZfp467zinc finger protein EZI
02
Biological functions
Adipocyte differentiationOsteoblast differentiation suppressionRegulation of gene expressionRecruitment of histone deacetylase complexesDNA binding
03
Disease associations
Other (alteration of adipocyte and osteoblast differentiation pathways may relate to metabolic or bone disorders, but no specific diseases are currently established)
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