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Zinc finger protein 470 (ZNF470)
- Target
- ZNF470
- Molecular classification
- Transcription factor, Zinc finger protein
01
Overview
Zinc finger protein 470 (ZNF470) is a member of the zinc finger protein family and encodes a putative DNA-binding transcription factor predicted to regulate gene expression through modulation of transcription by RNA polymerase II. ZNF470 is expressed in chondrocytes and its mRNA abundance varies in different stages of chondrogenesis, suggesting a possible role in cartilage development and homeostasis; it is not currently considered a direct therapeutic target or biomarker, nor are there known drugs that selectively modulate its activity. It is mapped to chromosome 19 and localizes to the nucleus, consistent with its function in the regulation of gene transcription.
- Other names
- CZF1CZF-1FLJ26175Chondrogenesis zinc finger protein 1zinc finger protein 470chondrogenesis zinc finger protein 1ZNF470
02
Biological functions
Regulation of transcription by RNA polymerase IIDNA-binding transcription factor activityNucleic acid bindingSequence-specific DNA binding
03
Disease associations
Other (reported association with denture stomatitis; expression implicated in chondrogenesis and possibly in osteoarthritis, but not a confirmed therapeutic disease target)
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