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Zinc finger protein 474 (ZNF474)

Target: ZNF474
Molecular classification: Transcription factor, Zinc finger protein (C2H2 type), SCAN domain-containing protein

Overview

Zinc finger protein 474 (ZNF474) is a member of the C2H2-type zinc finger protein family, characterized by its predicted zinc ion binding activity and structural features that suggest a role as a transcription factor[1][3][8]. ZNF474 contains a SCAN domain, a conserved protein-protein interaction motif implicated in the selective oligomerization of zinc finger proteins, and is predominantly found in the testis, suggesting possible functions in spermatogenesis or tissue-specific gene regulation[1][2][6]. ZNF474 shares structural motifs with other transcription factors but lacks direct evidence as a therapeutic target, and there are currently no drugs or validated biomarkers specifically associated with this protein. While zinc finger proteins as a family can be dysregulated in cancer, no specific disease link or safety concerns have been described for ZNF474 to date[4][1].

Other names: Zinc finger protein 474ZNF474TSZFP4933409D10RikFLJ32921Testis-specific zinc finger proteintestis-specific zinc finger protein

Biological functions

Metal ion binding (zinc ion binding)Predicted transcriptional regulation (by homology to other zinc finger proteins)

Disease associations

Other (no direct, validated disease associations reported as of 2025; some zinc finger proteins are involved in oncogenesis but ZNF474-specific data not identified)

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