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Target intelligence / Profile preview
Zinc finger protein 479 (ZNF479)
- Target
- ZNF479
- Molecular classification
- Transcription factor, C2H2-type zinc finger protein, KRAB-domain zinc finger protein
01
Overview
Zinc finger protein 479 is a member of the human C2H2-type zinc finger protein family, distinguished by its KRAB domain, which supports transcriptional regulation via DNA binding and recruitment of co-repressors or co-activators. ZNF479 was first identified in testis cDNA libraries and is expressed in various tissues. It is implicated in promoting cell proliferation and tumor growth in hepatocellular carcinoma, functioning in gene silencing and activation via modulation of target genes such as metallothionein-1 (MT-1) through regulatory proteins (e.g., ASH2L, DNMT1, UHRF1, Menin). Disruption or overexpression of ZNF479 alters cell growth, gene expression, and tumor phenotype, making it a candidate for future therapeutic targeting or biomarker utility in cancer biology.
- Other names
- ZNF479HKr19KR19Zinc finger protein Kr19KRAB zinc finger protein KR19
02
Mechanism of action
Not applicable/no drugs directly target ZNF479 at present; regulates gene expression through DNA binding
03
Biological functions
Transcriptional regulation (activating or repressing specific target genes)Cell proliferation (ZNF479 drives cell proliferation and anchorage-independent growth in experimental models)
04
Disease associations
Cancer (overexpressed in hepatocellular carcinoma; implicated in tumor growth and progression)Potential roles in other diseases, based on family behaviors (e.g., transcriptional dysregulation)
05
Safety considerations
Targeting transcription factors like ZNF479 could pose safety risks due to broad effects on gene expression, with possible impacts on cell growth and essential regulatory networks
06
Biomarkers
May serve as a biomarker for hepatocellular carcinoma, particularly for prognosis and disease association (high ZNF479 expression correlates with increased proliferation and poor prognosis)
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