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Target intelligence / Profile preview
Zinc finger protein 485 (ZNF485)
- Target
- ZNF485
- Molecular classification
- Transcription factor, Zinc finger protein
01
Overview
Zinc finger protein 485 (ZNF485) is a human protein encoded by the ZNF485 gene, functioning as a transcription factor of the C2H2 zinc finger family[2][3]. It is predicted to bind DNA and regulate transcription by RNA polymerase II, typically localizing to the nucleus[3][2]. ZNF485 is highly expressed in several cancers, particularly bladder cancer, where it promotes cancer cell proliferation, enhances mobility and invasion, and inhibits apoptosis; its suppression has been shown to reduce tumor growth in both cell lines and animal models[1]. Because of these roles, ZNF485 is considered both a biomarker and a potential therapeutic target in bladder cancer[1][2][3]. There is currently no well-documented evidence for direct drug interactions or validated mechanisms of pharmacological inhibition for ZNF485.
- Other names
- Zinc finger protein 485ZNF485ZN485_HUMANGC10P043256GC10P043421GC10P044101GC10P040628
02
Biological functions
Regulation of transcription by RNA polymerase IIDNA-binding transcription activator activityNucleic acid bindingRegulation of cell proliferationInhibition of apoptosis
03
Disease associations
Cancer (notably bladder cancer)
04
Biomarkers
Elevated ZNF485 expression serves as a prognostic and potential therapeutic biomarker in bladder cancer[1]
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