Zinc finger protein 486 (ZNF486)

Zinc finger protein 486 is a protein encoded by the human *ZNF486* gene. It belongs to the large family of KRAB domain-containing zinc finger transcription factors, which function primarily as DNA-binding proteins involved in transcriptional regulation. The KRAB domain typically acts as a potent transcriptional repression module by recruiting corepressor proteins such as KAP1/TRIM28, facilitating chromatin remodeling and gene silencing. While zinc finger proteins as a class are implicated in diverse processes—including DNA recognition, transcriptional activation, apoptosis regulation, protein folding, and lipid binding—ZNF486 itself is predicted, based on sequence analysis and gene ontology annotations, to participate in gene expression control, likely through RNA polymerase II cis-regulatory region sequence-specific DNA binding. Direct biological functions, disease associations, drug interactions, and biomarker utility for ZNF486 remain uncharacterized. The functional annotation largely follows what is known for the KRAB-zinc finger protein family, for which ZNF486 shares sequence and domain structure. There is no structural protein information available, and it is not known to be a druggable or disease-relevant target in clinical or experimental medicine.

Other names

ZNF486KRBO2MGC2396KRAB domain only protein 2zinc finger protein 486KRAB box only protein 2