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Zinc finger protein 492 (ZNF492)
- Target
- ZNF492
- Molecular classification
- Transcription factor, KRAB-zinc finger protein (Kruppel-associated box domain zinc finger family)
01
Overview
Zinc finger protein 492 is a human protein encoded by the ZNF492 gene, located on chromosome 19. It belongs to the KRAB-zinc finger protein family and is predicted to function as a DNA-binding transcription factor specific to RNA polymerase II regulatory regions[1][6][8]. ZNF492 is involved in the regulation of transcription and may act as a moderate transcriptional activator for the Rpe65 gene[6]. Its tissue localization is primarily nuclear, and it is expressed in multiple tissues[4]. ZNF492 is associated with congenital nongoitrous hypothyroidism, type 2, but has no established role as a therapeutic target or documented drug interactions[1][5][6].
- Other names
- ZNF492ZNF115KIAA1473Zinc finger protein 115zinc finger protein 492
02
Biological functions
Regulation of DNA-templated transcriptionDNA-binding transcription factor activity, RNA polymerase II-specificMay upregulate Rpe65 gene expression
03
Disease associations
Hypothyroidism, congenital, nongoitrous, type 2Other (no documented association with cancer, inflammation, or major disease roles besides rare congenital hypothyroidism)
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