Zinc finger protein 496 (ZNF496)

Zinc finger protein 496 (ZNF496) is a human protein-coding gene encoding a transcription factor of the zinc finger family, characterized by KRAB and SCAN domains, with 587 amino acids in its full-length form[1][2][4]. It binds DNA in a sequence-specific manner, both activating and repressing gene expression, and is functionally associated with regulation of transcription by RNA polymerase II[1][4]. ZNF496 interacts with JARID2, a regulator of neuronal differentiation, and mutations in ZNF496 (notably truncations affecting the C2H2 domain) have been identified as pathogenic in neurodevelopmental disorders, including intellectual disability and developmental delay[2]. While ZNF496 is genetically associated with Sotos syndrome and Weaver syndrome, it is not considered a direct therapeutic target and has no established role in drug development or patient biomarker usage[1][2][4].

Other names

ZNF496ZKSCAN17ZSCAN49Zinc finger protein with KRAB and SCAN domains 17NIZP1ZFP496MGC15548NSD1-interacting zinc finger protein 1

none known (no approved drugs or therapeutics acting via this target)