Zinc finger protein 501 (ZNF501)

Zinc finger protein 501 (ZNF501) is a member of the C2H2-type zinc finger transcription factor family, the largest family of sequence-specific DNA-binding proteins in humans[1][2][4][5]. ZNF501 binds to double-stranded DNA and is involved in the regulation of gene expression in the nucleus, as well as being implicated in the structural integrity of the Golgi apparatus[5]. Though its broad physiological roles are not fully delineated, ZNF501 mutations are associated with neurodevelopmental and neurodegenerative disorders such as autosomal dominant intellectual developmental disorder and frontotemporal dementia/amyotrophic lateral sclerosis[5]. Recent evidence also links ZNF501 to glioblastoma biology, where it supports tumor cell growth and stemness by maintaining the expression of Frizzled class receptor 6 (FZD6) and non-canonical Wnt signaling; silencing ZNF501 sensitizes glioblastoma cells to the chemotherapeutic agent temozolomide[3]. No currently approved drugs specifically target ZNF501, and its potential as a therapeutic target remains exploratory.

Other names

ZNF52MGC21738Zinc finger protein 52ZNFzinc finger protein 52

Likely involves modulation of gene expression, with observed drug sensitivity change upon ZNF501 ablation influencing glioblastoma cell response to temozolomide[3]