Zinc finger protein 507 (ZNF507)

Zinc finger protein 507 is a human protein encoded by the ZNF507 gene, classified within the C2H2-type zinc finger protein family[1][2][4][7]. It functions primarily as a transcription factor, enabling DNA and metal ion binding, and is predicted to be involved in the positive regulation of transcription by RNA polymerase II[1][6]. ZNF507 shows specificity for binding to certain young subfamilies of LINE-1 (L1) retrotransposon sequences, possibly targeting them for transcriptional regulation during development[2]. Evidence suggests it physically interacts with the chromatin-modifying enzyme PRMT5, potentially recruiting it to LINE-1 elements and influencing local chromatin states and gene expression[2]. ZNF507 is mainly localized in the cell nucleus and implicated as a risk locus in some neurodevelopmental disorders; mutations are associated with Seckel syndrome 6[1][2]. While zinc finger proteins as a class are being explored for their roles in cancer, genomic stability, and DNA repair, ZNF507 itself has not yet been directly established as a therapeutic target or related to any approved drugs[6].

Other names

ZNF507Zfp507KIAA1084