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Zinc finger protein 519 (ZNF519)
- Target
- ZNF519
- Molecular classification
- Transcription factor, C2H2-type zinc finger protein, DNA-binding protein
01
Overview
ZNF519 (Zinc finger protein 519) is a protein-coding gene in humans encoding a predicted DNA-binding transcription factor that locates to the nucleus and is thought to regulate DNA-templated transcription. It contains C2H2-type zinc finger domains, which are classic motifs enabling sequence-specific DNA interaction and chromatin binding. While the broader zinc finger protein family participates in numerous cellular and developmental processes, the precise biological role and mechanisms of ZNF519 remain incompletely understood. Mutations in ZNF519 have been genetically linked to rare inherited disorders such as Seckel syndrome and nonsyndromic congenital nail disorder, type 4. There is no current evidence supporting a direct role in cancer or as a therapeutic target, and no drugs are known to interact with ZNF519.
- Other names
- ZNF519HsT2362FLJ36809similar to zinc finger protein 85Zinc finger protein HPF4HTF1zinc finger protein 519
02
Biological functions
Regulation of DNA-templated transcriptionChromatin binding (predicted)
03
Disease associations
Genetic association with Seckel syndromeGenetic association with Nonsyndromic congenital nail disorder, type 4Other disease roles currently undefined; zinc finger proteins as a class are frequently implicated in cancer and neurodevelopment, but no direct evidence yet for ZNF519 specifically
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