Zinc finger protein 526 (ZNF526)

Zinc finger protein 526 (ZNF526) is a member of the zinc finger protein family characterized by the presence of C2H2-type zinc finger domains, which typically function as DNA-binding motifs involved in transcriptional regulation[2][3][1]. ZNF526 is predicted to enable sequence-specific DNA binding and participate in the regulation of gene expression by RNA polymerase II[3]. It is primarily localized to the cell nucleus[3]. Biallelic variants in ZNF526 have been associated with a severe neurodevelopmental disorder that includes microcephaly, epilepsy, bilateral cataracts, and simplified brain gyration[6][1]. There is no evidence that ZNF526 is currently considered a therapeutic target, nor are there known drugs that directly interact with this protein. Its main recognized relevance is in the context of rare congenital neurodevelopmental diseases[6][1].

Other names

ZNF526KIAA1951DENNEDMGC4267Zfp526D030024H03Rik