Zinc finger protein 552 (ZNF552)

Zinc finger protein 552 (ZNF552) is a human protein encoded by the ZNF552 gene, located on chromosome 19q13.43. It is a member of the Kruppel-associated box (KRAB) subfamily of C2H2-type zinc finger proteins, featuring an amino-terminal KRAB domain and seven carboxyl-terminal C2H2 zinc finger motifs. ZNF552 acts as a transcriptional repressor and inhibits the activity of transcription factors such as AP-1 and SRE, likely through its KRAB domain. The protein is primarily nuclear but also localizes to the cytoplasm in human tissues, with highest expression observed in the lung and testis. While it is predicted to play a role in gene expression regulation, ZNF552 is not currently recognized as a therapeutic target, and no direct disease associations, interacting drugs, or clinical biomarker applications are established.

Other names

ZNF552FLJ21603Zinc finger protein 552

Not applicable (no drugs targeting ZNF552; general mechanism is repression of AP-1 and SRE transcriptional activity via its KRAB domain if experimentally manipulated)