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Zinc finger protein 554 (ZNF554)
- Target
- ZNF554
- Molecular classification
- Transcription factor, C2H2 zinc finger protein, Krüppel-associated box (KRAB) domain protein
01
Overview
Zinc finger protein 554 (ZNF554) is a member of the large transcription factor family known as zinc finger proteins, specifically of the Krüppel-associated box (KRAB) domain-containing C2H2 zinc finger subfamily[2][1]. ZNF554 is encoded within the KRAB-ZNF cluster on chromosome 19p13. Its expression in humans is mainly limited to the brain and placenta[2]. Functionally, ZNF554 acts as a transcriptional regulator, involved in cell differentiation, embryo development, and epigenetic gene silencing. Recent studies show ZNF554 has tumor suppressor properties in brain cancers: its decreased expression in gliomas correlates with higher tumor grade and shorter patient survival, likely due to loss of suppression of oncogenic and immune-related pathways and dysregulation of cell proliferation and cell cycle control[2]. Decreased expression also contributes to the pathogenesis of preeclampsia by impairing trophoblast invasion[2]. There are currently no known drugs targeting ZNF554, nor reported safety concerns specific to its modulation.
- Other names
- FLJ34817ZNF554
02
Biological functions
Transcription regulationCell differentiationEmbryo developmentRegulation of cell cycleRegulation of cell proliferationEpigenetic silencing (via histone and DNA methylation)
03
Disease associations
Cancer (especially glioma, glioblastoma, and astrocytoma)Preeclampsia
04
Biomarkers
Decreased ZNF554 expression as a poor prognostic marker in glioma/glioblastoma
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