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Target intelligence / Profile preview
Zinc finger protein 558 (ZNF558)
- Target
- ZNF558
- Molecular classification
- Transcription factor, Zinc finger protein family
01
Overview
Zinc finger protein 558 is a DNA-binding transcription factor primarily found in the nucleus and is implicated in the regulation of transcription via RNA polymerase II. It is uniquely expressed in human forebrain neural progenitor cells—absent in chimpanzees—suggesting a role in human brain evolution and specifying developmental timing in neurogenesis. Mechanistically, ZNF558 evolved to repress LINE-1 transposons and has been adapted to regulate genes such as SPATA18, affecting mitochondrial homeostasis. Its expression is influenced by structural genomic variation, which may drive regulatory network changes during development
- Other names
- ZNF558Zinc finger protein 558FLJ30932GC19M008782GC19M008784GC19M008920GC19M008497
02
Mechanism of action
Not applicable; no drugs act on this target
03
Biological functions
Regulation of transcription by RNA polymerase IIDNA-binding transcription factor activityRepression of LINE-1 transposonsRegulation of mitophagy gene SPATA18, influencing mitochondrial homeostasisRegulation of neurogenesis and brain development
04
Disease associations
Cancer (specifically reported in association with endometrial mixed adenocarcinoma)Glycogen storage diseases (association indicated, mechanism not elaborated)Roles in brain development (developmental timing; no direct disease association established yet)
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