Zinc finger protein 559-Zinc finger protein 177 readthrough (ZNF559-ZNF177)

ZNF559-ZNF177 is a naturally occurring readthrough transcript between the neighboring zinc finger protein 559 (ZNF559) and zinc finger protein 177 (ZNF177) genes on chromosome 19[1][2][3][5]. This readthrough results in multiple transcript variants; however, the transcripts encode the ZNF177 protein, typically due to either inefficient start codon scanning or absence of the ZNF559 initiation codon[1]. The individual proteins ZNF559 and ZNF177 are zinc finger transcription factors predicted to be involved in nucleic acid binding, particularly in the regulation of transcription by RNA polymerase II[4][7][11]. There are currently no data supporting a direct disease association, known role as a therapeutic target, relevant interacting drugs, or usage as a biomarker for this readthrough entity[1][3][5]. The readthrough transcript itself is not generally considered a classical "therapeutic target" (such as a receptor, enzyme, transporter, or conventional transcription factor), and there is no evidence for a distinct functional protein product from this locus. The parental genes ZNF559 and ZNF177 are transcription factors, but the readthrough product does not appear to be functionally distinct. There is no evidence for its role in disease, interacting drugs, or as a biomarker. Given these factors, entries such as interacting drugs, disease roles, and mechanism of action are left null. Because the term represents a genomic readthrough and not a discrete protein or functional receptor, is_incorrect is set to true for reference as a therapeutic target.

Other names

ZNF559-ZNF177zinc finger protein 177ZNF559-ZNF177 readthrough