Zinc finger protein 568 (ZNF568)

Zinc finger protein 568 (ZNF568) is a member of the large zinc finger protein family, functioning primarily as a transcriptional repressor[3][4]. It contains two N-terminal KRAB (Krüppel-associated box) domains and an array of 11 C2H2 zinc fingers; this structure enables it to bind DNA and repress specific gene promoters, notably acting as a repressor of the placental-specific Igf2-P0 transcript in the mouse[1]. ZNF568 modulates gene expression in early embryonic development, particularly in extraembryonic tissue morphogenesis and convergent extension movements during gastrulation[1]. It establishes transcriptional silencing through recruitment of epigenetic modifiers such as histone methyltransferases, facilitating H3K9 methylation. The human ortholog appears to be evolutionarily conserved but may have species-specific diversifications in function[1][3]. There is currently no strong evidence that ZNF568 is a direct therapeutic target or interacts with drugs, nor has it been directly implicated as a biomarker or noted for clinical safety concerns in the literature to date[3][2].

Other names

ZNF568DKFZp686B0797ZFP568