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Target intelligence / Profile preview
Zinc finger protein 577 (ZNF577)
- Target
- ZNF577
- Molecular classification
- Transcription factor, Zinc finger protein, C2H2 zinc finger family
01
Overview
Zinc finger protein 577 (ZNF577) is a member of the zinc finger protein family, characterized by the presence of C2H2-type zinc finger motifs involved in binding DNA and regulating gene expression. ZNF577’s biological function has not been fully elucidated; however, it is thought to act as a transcription factor like other members of the zinc finger protein family[1][2]. Recent evidence has linked hypermethylation and decreased expression of ZNF577 to poorer clinical outcomes in lung adenocarcinoma, suggesting its potential utility as a prognostic biomarker[3]. There are no known drugs targeting ZNF577, nor are there confirmed mechanisms of drug action or specific safety concerns associated with therapeutic modulation of this protein. The precise role of ZNF577 in normal physiology and disease remains a topic of ongoing research[1][3].
- Other names
- ZNF577MGC4400
02
Biological functions
Transcriptional regulationPotential roles in DNA bindingChromatin remodeling (by zinc finger protein family context)Other (biological function of ZNF577 remains largely uncharacterized)
03
Disease associations
Cancer (specifically, involvement in lung adenocarcinoma through altered DNA methylation and regulation of expression)Other (potential roles in disease are anticipated based on zinc finger protein family but not confirmed for ZNF577 itself)
04
Biomarkers
DNA methylation status of ZNF577 (used as a prognostic biomarker in lung adenocarcinoma)mRNA expression level of ZNF577 (associated with prognosis in lung adenocarcinoma)
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