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Target intelligence / Profile preview
Zinc finger protein 589 (ZNF589)
- Target
- ZNF589
- Molecular classification
- Transcription factor, KRAB-zinc finger protein, DNA-binding protein, Krüppel-associated box domain zinc finger (KRAB-ZNF) protein, C2H2-type zinc finger protein
01
Overview
ZNF589 is a KRAB-zinc finger transcriptional repressor that plays critical roles in hematopoietic stem cell biology and cancer. It contains human-specific evolutionary changes and functions as a regulator of cell viability, apoptosis, and differentiation. The protein is downregulated in breast cancer through promoter hypermethylation and serves as a potential tumor suppressor and prognostic biomarker.
- Other names
- SZF1Stem cell zinc finger protein 1KRAB-zinc finger protein SZF1-1
02
Mechanism of action
Transcriptional repression by binding DNA and operating through RNA polymerase II-specific mechanisms, mediated by its KRAB domain which interacts with TRIM28 and recruits histone deacetylase complexes, histone methylases, and heterochromatin proteins.
03
Biological functions
Transcriptional repressionHematopoietic stem cell differentiationCell viability controlApoptosis regulationCell cycle regulationRegulation of hematopoietic stem cell hypoxic status
04
Disease associations
CancerBreast cancerHematopoietic disorders
05
Biomarkers
Prognostic biomarker for breast cancer overall survivalPrognostic biomarker for breast cancer relapse-free survival
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