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Zinc finger protein 594 (ZNF594)
- Target
- ZNF594
- Molecular classification
- Transcription factor, Zinc finger protein (C2H2-type superfamily, based on domain structure)
01
Overview
Zinc finger protein 594 is a human protein (807 amino acids) encoded by the ZNF594 gene and categorized as a C2H2-type zinc finger transcription factor[1][4]. It is thought to be involved in regulation of gene expression via sequence-specific DNA binding in the nucleoplasm, acting as a transcriptional activator associated with RNA polymerase II[4]. Like other zinc finger proteins, it contributes to complex regulation of genome expression, development, and cellular differentiation, but its precise biological roles remain incompletely characterized[1][2][5]. ZNF594 has been genetically associated with rare skeletal disorders such as metatropic dysplasia and brachyolmia, although the biological mechanism is not yet established[4]. It is not currently considered a direct therapeutic target or biomarker, and there are no clinically relevant drugs known to interact with it[4][1].
- Other names
- KIAA1871Zinc finger protein HZF18
02
Biological functions
Regulation of transcription by RNA polymerase IIDNA-binding transcription activator activity (sequence-specific)Possibly involved in embryonic development and differentiation, based on general functions of zinc finger proteins
03
Disease associations
Metatropic dysplasiaBrachyolmia (gene associations; no direct evidence for causation or mechanism)Other (zinc finger protein dysfunction broadly implicated in cancer, neurodevelopmental, and immune disorders, but no specific pathology uniquely attributed to ZNF594)
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